Genetic interaction between Caenorhabditis elegans teneurin ten-1 and prolyl 4-hydroxylase phy-1 and their function in collagen IV–mediated basement membrane integrity during late elongation of the embryo

摘要

A whole-genome RNAi screen identified phy-1 as a novel interaction partner of the Caenorhabditis elegans gene ten-1. It is shown that the catalytic subunit of prolyl 4-hydroxylase, which is coded for by phy-1, is important for type IV collagen secretion and that the transmembrane protein TEN-1 links the epidermis to muscle cells through the basement membrane.